Searching For Rare Cannabinoids in Non-Cannabis Plant Kingdom

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Unique glands extending from marijuana blossoms reveal a collection of special particles. Cannabinoids, as they are recognized, exist in marijuana Yet it ends up that similar particles exist in non-cannabis plants, also. Scientists from Israel’s Weizmann Institute lately reported that they located cannabigerolic acid (CBGA) and also various other unusual cannabinoids in Helichrysum umbraculigerum, a seasonal bush informally called the woolly umbrella. 1

A South African Agricultural

Ferdinand Bohlmann and also Evelyn Hoffman initially reviewed the chemical abnormality of Helichrysum. In a 1979 paper released in Phytochemistry 2, they assessed the South African types H. umbraculigerum, belonging to the eastern component of the nation, where it was made use of in conventional medication and also airing out routines.

Bohlmann and also Hoffman insisted that the plant’s tops– both fallen leaves and also blossoms– generate cannabis-specific substances. Yet a follow-up research carried out by Italian scientists in 2017 stopped working to discover CBG or its acidic forerunner in H. umbraculigerum blossoms. They did, nevertheless, recognize an analog of CBG called Heli-CBG (additionally existing in some fiber hemp varietals), which binds to the CB2 cannabinoid receptor. 3,4

In a Might 2023 short article in Nature Plants, Weissman Institute researchers verified that woolly umbrella creates CBGA in trichomes on its fallen leaves, yet little CBGA existed on its blossoms. That’s various from marijuana, where CBGA and also various other cannabinoids are focused in trichomes on blossom tops. 1

Trichomes located on marijuana florescence (blossoms) have an unique mobile develop, according to a 2022 research by College of British Columbia scientists in Present Biology The gland’s spheric head holds big permeable cells that allow acidic cannabinoids (CBGA, CBDA, THCA, and so on) relocation via the trichome. 5 The Weizmann Institute group reported that H. umbraculigerum creates a comparable cannabinoid transportation network on its fallen leaves. 1

Sourcing Uncommon Cannabinoids in Non-Cannabis Hedges

Just How did the Israeli researchers figure this out? They fed woolly umbrella forerunner substances in charge of making cannabinoids in marijuana. When offered 2 forerunners (hexanoic acid and also phenylalanine), the bush generated even more cannabinoids contrasted to plants fed routine nutrients. This indicates that the very same biosynthetic path exists in both marijuana blossoms and also woolly umbrella leaves.

The woolly umbrella bush normally creates on its fallen leaves over 4% cannabigerolic acid together with various other unusual cannabinoids. The bush additionally has water-soluble cannabinoids, which are not located in marijuana.

Basically, 2 various plant types have actually established the very same equipment to generate CBGA. Yet, woolly umbrella is evolutionarily unique from marijuana. And also unlike the bush, marijuana makes 2 special enzymes that turn CBGA right into either THCA and/or CBDA.

Discovering a New Phytocannabinoid Toolkit

Therefore, there are 2 tool kits for cannabinoid phyto-synthesis in the phylogenetic tree. Terpenes and also a couple of flavonoids come with lipophilic marijuana blossoms, whereas a complicated range of flavones and also water-soluble cannabinoids establish in H. umbraculigerum. By comprehending their resemblances and also distinctions, we can much better evaluate the healing possibility of each plant.

Cannabinoid substances located in woolly umbrella liquify even more conveniently in water and also can target details locations of the body, such as the much deeper digestive tract. Yet better bioavailability, a debate for water-soluble cannabinoids, is not always equal to better strength. That which is taken in promptly and also conveniently additionally leaves the body and also sheds effectiveness quicker. And also cannabinoid receptors have much more fondness for fat-loving substances contrasted to water-soluble agonists. 6,7

Travis Cesarone is a self-employed author and also communicator concentrating on clinical marijuana scientific researches. © Copyright, Job CBD. Might not be reprinted without approval.


  1. Berman, P., de Haro, L.A., Jozwiak, A. et al. Identical development of cannabinoid biosynthesis. Nat. Plants ( 2023 ).
  2. Cannabigerol-ähnliche verbindungen aus Helichrysum umbraculigerum. Phytochemistry 1979; 18( 8 ):1371 -1374.
  3. Pollastro, F., De Petrocellis, L., Schiano-Moriello, A., Chianese, G., Heyman, H., Appendino, G., & & Taglialatela-Scafati, O. (2017 ). Amorfrutin-type phytocannabinoids from Helichrysum umbraculigerum. Fitoterapia, 123, 13– 17.
  4. Pollastro F, Taglialatela-Scafati O, Allarà M, Muñoz E, Di Marzo V, De Petrocellis L, Appendino G. Bioactive prenylogous cannabinoid from fiber hemp (Marijuana sativa). J Nat Prod. 2011 Sep 23; 74( 9 ):2019 -22. doi: 10.1021/ np200500p. Epub 2011 Sep 8. PMID: 21902175.
  5. Livingston, S. J., Rensing, K. H., Web Page, J. E., & & Samuels, A. L. (2022 ). A polarized supercell creates specialized metabolites in marijuana trichomes. Present biology: CB, 32( 18 ), 4040– 4047. e4.
  6. Li, X., Chang, H., Bouma, J. et al.. Architectural basis of careful cannabinoid CB2 receptor activation. Nat Commun 14, 1447 (2023 ).
  7. Stadel, R., Ahn, K. H., & & Kendall, D. A. (2011 ). The cannabinoid type-1 receptor carboxyl-terminus, greater than simply a tail. Journal of neurochemistry, 117( 1 ), 1– 18.

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